The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune checkpoint blockade therapy.

Nature Communications - Resting T cells are difficult to manipulate, and are a reservoir for latent HIV. Here, the authors develop a lipid nanoparticle formulation with the ability to transfect...

Read about ‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

Breastfeeding seems to cause specialised immune cells to flood into the breasts and stay there for years or even decades, reducing the risk of cancer

Tumor metabolism selectively enriches Tregs to achieve immunosuppression, but the
underlying mechanisms remain unclear. Here, we show that tumor-derived ammonia drives
Treg-specific enrichment. Tregs detoxify ammonia via the urea cycle and spermine synthesis…

The types of fats we consume directly impacts the survival and strength of the body’s immune cells and ability to fight disease, researchers have found.