Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity (Gu et al, 2025) 🦠💔🧬
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#TumorImmunity #Tcells #CancerResearch #Metabolism #Immunotherapy
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#TumorImmunity #Tcells #CancerResearch #Metabolism #Immunotherapy
Cell
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity
Tumor metabolism selectively enriches Tregs to achieve immunosuppression, but the
underlying mechanisms remain unclear. Here, we show that tumor-derived ammonia drives
Treg-specific enrichment. Tregs detoxify ammonia via the urea cycle and spermine synthesis…
underlying mechanisms remain unclear. Here, we show that tumor-derived ammonia drives
Treg-specific enrichment. Tregs detoxify ammonia via the urea cycle and spermine synthesis…
Researchers use CRISPR to "unlock" immune cells' power against solid tumors. In a mouse study, researchers found they can use CRISPR to delete a gene called FLI1 to enhance human killer cell survival after tumor infiltration.
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#CRISPRImmunity #CancerResearch #TumorImmunity #ImmuneCellTherapy #ScienceBreakthrough
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#CRISPRImmunity #CancerResearch #TumorImmunity #ImmuneCellTherapy #ScienceBreakthrough
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UCLA researchers use CRISPR to "unlock" immune cells' power against solid tumors
By using CRISPR technology to delete a specific gene called FLI1, researchers were able to significantly enhance the ability of Natural Killer (NK) cells to survive and inhibit solid tumor growth.