In Long Covid, Covid-19 RNA persistence and T-Cell activation found up to two years after infection.
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#LongCovid #COVID19 #RNAPersistence #TCellActivation #ImmuneResponse
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#LongCovid #COVID19 #RNAPersistence #TCellActivation #ImmuneResponse
Science Translational Medicine
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection
Total-body PET imaging and microscopy analysis of rectosigmoid biopsies reveal prolonged T cell activation and SARS-CoV-2 RNA persistence following COVID-19.
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Previously unknown mechanism of inflammation shows in mice Covid spike protein directly binds to blood protein fibrin, cause of unusual clotting. Also activates destructive immune response in the brain, likely cause of reduced cognitive function. Immunotherapy progressed to Phase 1 clinical trials.
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#CovidResearch #InflammationMechanism #ImmuneResponse #ClinicalTrials #CognitiveHealth
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#CovidResearch #InflammationMechanism #ImmuneResponse #ClinicalTrials #CognitiveHealth
Nature
Fibrin drives thromboinflammation and neuropathology in COVID-19
Nature - Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
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Murine Study Finds Multi-Dose Vaccines Administered in the Same Site Boost Immune Response
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#MurineStudy #MultiDoseVaccines #ImmuneResponse #VaccineResearch #HealthInnovation
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#MurineStudy #MultiDoseVaccines #ImmuneResponse #VaccineResearch #HealthInnovation
AAI News
Multi-Dose Vaccines Administered in the Same Site Boost Immune Response - AAI News
New research suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development.
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A Phase 1/2 trial of Moderna’s mRNA-1083 found strong immune responses against both viruses, similar to existing vaccines. Most side effects were mild.
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#Moderna #mRNA1083 #VaccineResearch #ImmuneResponse #ClinicalTrials
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#Moderna #mRNA1083 #VaccineResearch #ImmuneResponse #ClinicalTrials
Nature
mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine in healthy adults: a phase 1/2 trial
Nature Medicine - An interim analysis shows that a new mRNA influenza and SAR-CoV-2 combination vaccine is safe and triggers an encouraging immune response.
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Receiving a booster vaccine in the same arm as your first dose 💉 can generate a more effective immune response 💪 more quickly ⏱️.
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#vaccinesafety #immuneresponse #boosterdose #healthawareness #publichealth
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#vaccinesafety #immuneresponse #boosterdose #healthawareness #publichealth
UNSW Sydney
Left or right arm? New research reveals why vaccination site matters for immune response
Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.
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Study links the body’s immune response with schizophrenia 🧠, Alzheimer’s disease 🧓, depression 😢, and bipolar disorder ⚖️.
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#ImmuneResponse #MentalHealth #Schizophrenia #AlzheimersDisease #DepressionResearch
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#ImmuneResponse #MentalHealth #Schizophrenia #AlzheimersDisease #DepressionResearch
University of Bristol
Depression and other mental health conditions linked with immune response, study finds
Most people with depression or schizophrenia are treated with drugs that work on brain chemicals such as serotonin and dopamine. However, 1 in 3 people with these conditions do not benefit from these treatments, suggesting that other mechanisms are involved.
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Experimental Therapy Suppresses Immune Reaction to Gluten in Mice 🧪🧬🐭
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#ExperimentalTherapy #GlutenSensitivity #ImmuneResponse #MiceResearch #HealthInnovation
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#ExperimentalTherapy #GlutenSensitivity #ImmuneResponse #MiceResearch #HealthInnovation
ScienceAlert
Experimental Therapy Suppresses Immune Reaction to Gluten in Mice
New hopes for a treatment for celiac disease.
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Fructose hijacks immune cells to set them on inflammatory "attack mode" ⚔️🩸 | In this "trigger happy" state, certain immune cells are less discerning, resulting in inflammation, more severe infections and even new food intolerances or sensitivities. 🍽️💥
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#FructoseInflammation #ImmuneResponse #HealthAwareness #FoodIntolerances #ChronicInflammation
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#FructoseInflammation #ImmuneResponse #HealthAwareness #FoodIntolerances #ChronicInflammation
New Atlas
Fructose hijacks immune cells to set them on inflammatory "attack mode"
For the first time, scientists have unraveled just how high levels of fructose affect the body, flipping a genetic switch as it's broken down – one that primes your immune system to overreact to things it would normally ignore. In this "trigger happy" state…
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Study reveals that white sugar doesn’t just feed bacteria in your gut 🍬 – it rewires them 🔄. Looking at cell culture, mice 🐭 and humans 👤, researchers discovered that consuming sugar can trigger physical flips in bacterial DNA, setting off a chain reaction that alters immune responses and gut health.
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#GutHealth #SugarImpact #MicrobiomeResearch #ImmuneResponse #HealthScience
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#GutHealth #SugarImpact #MicrobiomeResearch #ImmuneResponse #HealthScience
New Atlas
This common food turns your gut into a bacteria-shapeshifting war zone
A groundbreaking study has revealed that white sugar doesn’t just feed the bacteria in your gut – it rewires them. Researchers have discovered that consuming sugar can trigger physical flips in bacterial DNA, setting off a chain reaction that alters immune…
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Comparative analyses for plant virus-based cancer immunotherapy drug development 🌱🦠 - Plant virus triggers immune response that targets and destroys cancer cells 💪🏽🎗️
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#PlantVirus #CancerImmunotherapy #DrugDevelopment #ImmuneResponse #CancerResearch
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#PlantVirus #CancerImmunotherapy #DrugDevelopment #ImmuneResponse #CancerResearch
Cell Biomaterials
Comparative analyses for plant virus-based cancer immunotherapy drug development
Cowpea mosaic virus (CPMV) is a plant virus that has been repurposed as an intratumoral
immunotherapy agent. Its anti-tumor efficacy is unique when compared with other plant
viruses. The focus of this work is to identify the key determinants that set CPMV…
immunotherapy agent. Its anti-tumor efficacy is unique when compared with other plant
viruses. The focus of this work is to identify the key determinants that set CPMV…
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Study shows Lyme Disease can disrupt gut bacteria 🦠 and immune response 🛡️
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#LymeDisease #GutHealth #ImmuneResponse #Microbiome #HealthResearch
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#LymeDisease #GutHealth #ImmuneResponse #Microbiome #HealthResearch
mBio
Borreliosis and doxycycline treatment disrupt gut microbiota and immune responses in nonhuman primates | mBio
Lyme disease (LD) is caused by Borrelia burgdorferi (Bb) transmitted via tick bite. The incidence of LD is expanding in North America
and Southeast Asia. LD patients are frequently misdiagnosed or receive delayed treatment
due to the lack of sensitive diagnostic…
and Southeast Asia. LD patients are frequently misdiagnosed or receive delayed treatment
due to the lack of sensitive diagnostic…
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ALS Breakthrough Shows Fatal Disease Is Driven by Immune Attack 🧠💔🛡️
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#ALSBreakthrough #ImmuneResponse #NeurodegenerativeDiseases #ResearchInnovation #HealthAwareness
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#ALSBreakthrough #ImmuneResponse #NeurodegenerativeDiseases #ResearchInnovation #HealthAwareness
Bloomberg.com
ALS Breakthrough Shows Fatal Disease Is Driven by Immune Attack
Researchers have uncovered how the body’s own immune system may be driving the progression of amyotrophic lateral sclerosis, or ALS — a breakthrough that could reshape treatment of the fatal disease.
Researchers at the University of Washington in Seattle have shown that an mRNA version of a covid-19 nanoparticle vaccine produces an immune response in mice 🐭 that is up to 28 times higher 🔬 than that of a standard mRNA vaccine.
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#Covid19Vaccine #mRNAVaccine #NanoparticleResearch #ImmuneResponse #VaccinationInnovation
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#Covid19Vaccine #mRNAVaccine #NanoparticleResearch #ImmuneResponse #VaccinationInnovation
New Scientist
Why the next generation of mRNA vaccines is set to be even better | New Scientist
mRNA vaccines are quick and easy to make, while virus-like nanoparticles produce a stronger immune response. Now, the two approaches are being combined to give us the best of both worlds
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Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination, finds a new study in a mouse model. 🐭💉 The results inform the general public regarding the potential risk of tattooing practice associated with an altered immune response. 🎨⚠️
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#TattooResearch #ImmuneResponse #HealthAwareness #BodyArtScience #VaccinationRisks
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#TattooResearch #ImmuneResponse #HealthAwareness #BodyArtScience #VaccinationRisks
PNAS
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination
Despite safety concerns regarding the toxicity of tattoo ink, no studies have reported the consequences of tattooing on the immune response. In thi...
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The study reveals that macrophages, key immune cells, fail to properly clear dead and drying cells after peripheral nerve injury, contributing to chronic pain development. 🦠🩹💔
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#Macrophages #ChronicPain #NerveInjury #ImmuneResponse #PainResearch
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#Macrophages #ChronicPain #NerveInjury #ImmuneResponse #PainResearch
PNAS
Peripheral nerve injury reduces macrophage efferocytosis to facilitate neuropathic pain
For reasons not fully understood, proresolving immune processes sometimes fail to engage after peripheral nerve injury (PNI), leading to enhanced n...
The immune system’s reaction to the common Epstein-Barr Virus (EBV) can damage the brain 🧠 and contribute to multiple sclerosis (MS) 🦠. A recent study provides new insight into the long-suspected link between EBV and MS - Long-term memory T-cells pick on the wrong protein (ANO2) instead of EBV-antigen.
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#EpsteinBarrVirus #MultipleSclerosis #ImmuneResponse #BrainHealth #MedicalResearch
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#EpsteinBarrVirus #MultipleSclerosis #ImmuneResponse #BrainHealth #MedicalResearch
Today's Clinical Lab
New Mechanism Links Epstein-Barr Virus to Multiple Sclerosis
Exactly how Epstein-Barr virus contributes to MS has long been unclear
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A single session of Finnish sauna bathing significantly increases circulating immune cells, such as neutrophils and monocytes, with the effect being more pronounced than changes in inflammatory cytokines (n=51).
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#SaunaHealth #ImmuneResponse #FinnishSauna
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#SaunaHealth #ImmuneResponse #FinnishSauna
Taylor & Francis
Acute Finnish sauna heat exposure induces stronger immune cell than cytokine responses
Regular exposure to Finnish sauna bathing (FSB) has been associated with reduced morbidity and mortality. This study aimed to examine the acute effects of FSB on immune cell mobilization, circulati...
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